Brugia malayi in Mastomys natalensis: efficacy of mebendazole in combination with Freund's complete adjuvant.
Identifieur interne : 00D162 ( Main/Exploration ); précédent : 00D161; suivant : 00D163Brugia malayi in Mastomys natalensis: efficacy of mebendazole in combination with Freund's complete adjuvant.
Auteurs : P K Murthy [Inde] ; K. Tyagi ; R K ChatterjeeSource :
- Folia parasitologica [ 0015-5683 ] ; 1992.
Descripteurs français
- KwdFr :
- Adjuvant Freund (administration et posologie), Adjuvant Freund (usage thérapeutique), Administration par voie orale, Animaux, Anticorps antihelminthe (biosynthèse), Brugia (), Brugia (immunologie), Filariose lymphatique (sang), Filariose lymphatique (traitement médicamenteux), Injections péritoneales, Injections sous-cutanées, Microfilaria (), Muridae, Mébendazole (administration et posologie), Mébendazole (pharmacologie), Mébendazole (usage thérapeutique).
- MESH :
- administration et posologie : Adjuvant Freund, Mébendazole.
- biosynthèse : Anticorps antihelminthe.
- immunologie : Brugia.
- pharmacologie : Mébendazole.
- sang : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Adjuvant Freund, Mébendazole.
- Administration par voie orale, Animaux, Brugia, Injections péritoneales, Injections sous-cutanées, Microfilaria, Muridae.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Antibodies, Helminth (biosynthesis), Brugia (drug effects), Brugia (immunology), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (drug therapy), Freund's Adjuvant (administration & dosage), Freund's Adjuvant (therapeutic use), Injections, Intraperitoneal, Injections, Subcutaneous, Mebendazole (administration & dosage), Mebendazole (pharmacology), Mebendazole (therapeutic use), Microfilariae (drug effects), Muridae.
- MESH :
- chemical , administration & dosage : Freund's Adjuvant, Mebendazole.
- chemical , biosynthesis : Antibodies, Helminth.
- blood : Elephantiasis, Filarial.
- drug effects : Brugia, Microfilariae.
- drug therapy : Elephantiasis, Filarial.
- immunology : Brugia.
- chemical , pharmacology : Mebendazole.
- chemical , therapeutic use : Freund's Adjuvant, Mebendazole.
- Administration, Oral, Animals, Injections, Intraperitoneal, Injections, Subcutaneous, Muridae.
Abstract
The chemotherapeutic efficacy of mebendazole given in combination with Freund's complete adjuvant (FCA) against Brugia malayi in multimammate rat was evaluated. Animals treated with mebendazole, orally at 200 mg/kg x 5 consecutive days along with FCA given subcutaneously (s.c.) on day -10, day 0 and day +15 of the drug treatment killed 48.51% of the adult worms. This drug given alone at the same regimen and by the same route showed only 18.7% mortality rate on adults. Mebendazole given intraperitoneally along with FCA given s.c., however, was four times more efficacious as filaricide than mebendazole alone. Nevertheless, the animals receiving FCA alone also revealed 23.5% mortality rate of adult worms. The animals receiving a combination therapy or FCA alone showed significant increase in antibody titre to the filariae which however decreased in the later stages. No enhancement of antibody level could be detected in animals treated with mebendazole alone. The non-specific immunopotentiation induced by FCA appeared to play a major role in enhancing the activity of mebendazole.
PubMed: 1644349
Affiliations:
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Tyagi</name></author><author><name sortKey="Chatterjee, R K" sort="Chatterjee, R K" uniqKey="Chatterjee R" first="R K" last="Chatterjee">R K Chatterjee</name></author></analytic><series><title level="j">Folia parasitologica</title><idno type="ISSN">0015-5683</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Antibodies, Helminth (biosynthesis)</term><term>Brugia (drug effects)</term><term>Brugia (immunology)</term><term>Elephantiasis, Filarial (blood)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Freund's Adjuvant (administration & dosage)</term><term>Freund's Adjuvant (therapeutic use)</term><term>Injections, Intraperitoneal</term><term>Injections, Subcutaneous</term><term>Mebendazole (administration & dosage)</term><term>Mebendazole (pharmacology)</term><term>Mebendazole (therapeutic use)</term><term>Microfilariae (drug effects)</term><term>Muridae</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvant Freund (administration et posologie)</term><term>Adjuvant Freund (usage thérapeutique)</term><term>Administration par voie orale</term><term>Animaux</term><term>Anticorps antihelminthe (biosynthèse)</term><term>Brugia ()</term><term>Brugia (immunologie)</term><term>Filariose lymphatique (sang)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Injections péritoneales</term><term>Injections sous-cutanées</term><term>Microfilaria ()</term><term>Muridae</term><term>Mébendazole (administration et posologie)</term><term>Mébendazole (pharmacologie)</term><term>Mébendazole (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Freund's Adjuvant</term><term>Mebendazole</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Helminth</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvant Freund</term><term>Mébendazole</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antihelminthe</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brugia</term><term>Microfilariae</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Mébendazole</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Mebendazole</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Freund's Adjuvant</term><term>Mebendazole</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Adjuvant Freund</term><term>Mébendazole</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Injections, Intraperitoneal</term><term>Injections, Subcutaneous</term><term>Muridae</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Animaux</term><term>Brugia</term><term>Injections péritoneales</term><term>Injections sous-cutanées</term><term>Microfilaria</term><term>Muridae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The chemotherapeutic efficacy of mebendazole given in combination with Freund's complete adjuvant (FCA) against Brugia malayi in multimammate rat was evaluated. Animals treated with mebendazole, orally at 200 mg/kg x 5 consecutive days along with FCA given subcutaneously (s.c.) on day -10, day 0 and day +15 of the drug treatment killed 48.51% of the adult worms. This drug given alone at the same regimen and by the same route showed only 18.7% mortality rate on adults. Mebendazole given intraperitoneally along with FCA given s.c., however, was four times more efficacious as filaricide than mebendazole alone. Nevertheless, the animals receiving FCA alone also revealed 23.5% mortality rate of adult worms. The animals receiving a combination therapy or FCA alone showed significant increase in antibody titre to the filariae which however decreased in the later stages. No enhancement of antibody level could be detected in animals treated with mebendazole alone. The non-specific immunopotentiation induced by FCA appeared to play a major role in enhancing the activity of mebendazole.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Chatterjee, R K" sort="Chatterjee, R K" uniqKey="Chatterjee R" first="R K" last="Chatterjee">R K Chatterjee</name><name sortKey="Tyagi, K" sort="Tyagi, K" uniqKey="Tyagi K" first="K" last="Tyagi">K. Tyagi</name></noCountry><country name="Inde"><noRegion><name sortKey="Murthy, P K" sort="Murthy, P K" uniqKey="Murthy P" first="P K" last="Murthy">P K Murthy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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